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Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells.
Stone, Oliver A; El-Brolosy, Mohamed; Wilhelm, Kerstin; Liu, Xiaojing; Romão, Ana M; Grillo, Elisabetta; Lai, Jason K H; Günther, Stefan; Jeratsch, Sylvia; Kuenne, Carsten; Lee, I-Ching; Braun, Thomas; Santoro, Massimo M; Locasale, Jason W; Potente, Michael; Stainier, Didier Y R.
Afiliación
  • Stone OA; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany. oliver.stone@dpag.ox.ac.uk.
  • El-Brolosy M; Department of Physiology, Anatomy and Genetics, BHF Centre of Research Excellence, University of Oxford, Oxford, OX1 3PT, UK. oliver.stone@dpag.ox.ac.uk.
  • Wilhelm K; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Liu X; Angiogenesis & Metabolism Laboratory, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Romão AM; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
  • Grillo E; Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Lai JKH; Department of Oncology, KUL, Herestraat 49, 3000, Leuven, Belgium.
  • Günther S; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Jeratsch S; Mechanobiology Institute, National University of Singapore, Singapore, 117411, Singapore.
  • Kuenne C; ECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Lee IC; Biomolecular Mass Spectrometry, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Braun T; ECCPS Bioinformatics and Deep Sequencing Platform, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Santoro MM; Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Locasale JW; Department of Cardiac Development and Remodelling, Max Planck Institute for Heart and Lung Research, Ludwigstrasse 43, 61231, Bad Nauheim, Germany.
  • Potente M; Department of Biology, University of Padua, Viale Giuseppe Colombo 3, 10141, Padua, Italy.
  • Stainier DYR; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, 27710, USA.
Nat Commun ; 9(1): 4077, 2018 10 09.
Article en En | MEDLINE | ID: mdl-30301887
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piruvato Quinasa / Hormonas Tiroideas / Transducción de Señal / Proteínas Portadoras / Células Endoteliales / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Alemania
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Piruvato Quinasa / Hormonas Tiroideas / Transducción de Señal / Proteínas Portadoras / Células Endoteliales / Proteínas de la Membrana Límite: Animals / Humans Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2018 Tipo del documento: Article País de afiliación: Alemania