A ratiometric fluorescent BODIPY-based probe for rapid and highly sensitive detection of cysteine in human plasma.
Analyst
; 143(23): 5728-5735, 2018 Nov 19.
Article
en En
| MEDLINE
| ID: mdl-30320848
ABSTRACT
Biological thiols, especially low molecular weight thiols, including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH), play a pivotal role in physiological and pathological systems. Thus, the detection of biothiols is highly important for early diagnosis of diseases and evaluation of disease progression. Herein, we developed a highly selective and sensitive ratiometric fluorescent 8-Cl BODIPY-based probe with high fluorescence quantum yields. The probe displayed a sensitive response to Cys and Hcy over other biothiols, which can be visualized colorimetrically and/or fluorescently. The probe was successfully applied to detect Cys in human plasma, demonstrating its great value for practical application in biological sample analysis.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Boro
/
Cisteína
/
Colorantes Fluorescentes
Tipo de estudio:
Diagnostic_studies
/
Screening_studies
Límite:
Humans
Idioma:
En
Revista:
Analyst
Año:
2018
Tipo del documento:
Article