Inhibitors of 17ß-hydroxysteroid dehydrogenase type 1, 2 and 14: Structures, biological activities and future challenges.
Mol Cell Endocrinol
; 489: 66-81, 2019 06 01.
Article
en En
| MEDLINE
| ID: mdl-30336189
ABSTRACT
During the past 25 years, the modulation of estrogen action by inhibition of 17ß-hydroxysteroid dehydrogenase types 1 and 2 (17ß-HSD1 and 17ß-HSD2), respectively, has been pursued intensively. In the search for novel treatment options for estrogen-dependent diseases (EDD) and in order to explore estrogenic signaling pathways, a large number of steroidal and nonsteroidal inhibitors of these enzymes has been described in the literature. The present review gives a survey on the development of inhibitor classes as well as the structural formulas and biological properties of their most interesting representatives. In addition, rationally designed dual inhibitors of both 17ß-HSD1 and steroid sulfatase (STS) as well as the first inhibitors of 17ß-HSD14 are covered.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Inhibidores Enzimáticos
/
17-Hidroxiesteroide Deshidrogenasas
Límite:
Humans
Idioma:
En
Revista:
Mol Cell Endocrinol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania