Monotopic Membrane Proteins Join the Fold.
Trends Biochem Sci
; 44(1): 7-20, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30337134
ABSTRACT
Monotopic membrane proteins, classified by topology, are proteins that embed into a single face of the membrane. These proteins are generally underrepresented in the Protein Data Bank (PDB), but the past decade of research has revealed new examples that allow the description of generalizable features. This Opinion article summarizes shared characteristics including oligomerization states, modes of membrane association, mechanisms of interaction with hydrophobic or amphiphilic substrates, and homology to soluble folds. We also discuss how associations of monotopic enzymes in pathways can be used to promote substrate specificity and product composition. These examples highlight the challenges in structure determination specific to this class of proteins, but also the promise of new understanding from future study of these proteins that reside at the interface.
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1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas de la Membrana
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2019
Tipo del documento:
Article