Coumarinolignoids and Taraxerane Triterpenoids from Sapium discolor and Their Inhibitory Potential on Microglial Nitric Oxide Production.
J Nat Prod
; 81(10): 2251-2258, 2018 10 26.
Article
en En
| MEDLINE
| ID: mdl-30350995
ABSTRACT
Seventeen compounds, including three new pairs of coumarinolignoid enantiomers, (7' S,8' S)-sapiumins A-C (1a-3a) and (7' R,8' R)-sapiumins A-C (1b-3b), six new taraxerane triterpenoids, sapiumic acids A-F (4-9), and five known taraxerane triterpenoids (10-14), were isolated from an ethanol extract prepared from the stems and leaves of Sapium discolor. The structures of 1-9 and their relative configurations were determined by spectroscopic data analysis, and the absolute configurations of the coumarinolignoids 1a/1b-3a/3b and triterpenoids 6-9 were assigned using experimental and calculated ECD data. Compounds 1a/1b-3a/3b are the first coumarinolignoids to be reported from the genus Sapium. Among all the isolates, compounds 1b, 2a/2b, 3a/3b, and 6-9 inhibited nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells, with IC50 values of 1.7-15.3 µM.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácido Oleanólico
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Triterpenos
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Microglía
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Cumarinas
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Sapium
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Óxido Nítrico
Límite:
Humans
Idioma:
En
Revista:
J Nat Prod
Año:
2018
Tipo del documento:
Article