Enhanced interaction between SEC2 mutant and TCR Vß induces MHC II-independent activation of T cells via PKCÎ¸/NF-&#954;B and IL-2R/STAT5 signaling pathways.

Fu, Xuanhe; Xu, Mingkai; Song, Yubo; Li, Yongqiang; Zhang, Huiwen; Zhang, Jinghai; Zhang, Chenggang

Enhanced interaction between SEC2 mutant and TCR Vß induces MHC II-independent activation of T cells via PKCÎ¸/NF-κB and IL-2R/STAT5 signaling pathways.

Fu, Xuanhe; Xu, Mingkai; Song, Yubo; Li, Yongqiang; Zhang, Huiwen; Zhang, Jinghai; Zhang, Chenggang.

Afiliación

Fu X; From the Institute of Applied Ecology, Chinese Academy of Sciences, 72 WenHua Road, Shenyang 110016, China and.
Xu M; the School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 WenHua Road, Shenyang 110016, China.
Song Y; From the Institute of Applied Ecology, Chinese Academy of Sciences, 72 WenHua Road, Shenyang 110016, China and mkxu@iae.ac.cn.
Li Y; From the Institute of Applied Ecology, Chinese Academy of Sciences, 72 WenHua Road, Shenyang 110016, China and.
Zhang H; From the Institute of Applied Ecology, Chinese Academy of Sciences, 72 WenHua Road, Shenyang 110016, China and.
Zhang J; From the Institute of Applied Ecology, Chinese Academy of Sciences, 72 WenHua Road, Shenyang 110016, China and.
Zhang C; the School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, 103 WenHua Road, Shenyang 110016, China zhangjinghai@foxmail.com.

J Biol Chem ; 293(51): 19771-19784, 2018 12 21.

Article en En | MEDLINE | ID: mdl-30352872

Asunto(s)

Enterotoxinas/genética; Activación de Linfocitos; Mutación; Receptores de Antígenos de Linfocitos T/metabolismo; Transducción de Señal; Linfocitos T/inmunología; Animales; Proliferación Celular; Enterotoxinas/metabolismo; Femenino; Regulación de la Expresión Génica/inmunología; Antígenos de Histocompatibilidad Clase II/metabolismo; Interleucina-2/metabolismo; Ratones; Ratones Endogámicos BALB C; FN-kappa B/metabolismo; Fosforilación; Proteína Quinasa C-theta/metabolismo; Receptores de Interleucina-2/metabolismo; Factor de Transcripción STAT5/metabolismo; Bazo/inmunología; Linfocitos T/citología

Palabras clave

IL-2; NF-κB (NF-KB); STAT transcription factor; T-cell activation; T-cell receptor; interleukin; signal transduction; signaling; staphylococcal enterotoxin C2; superantigen

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Activación de Linfocitos / Receptores de Antígenos de Linfocitos T / Linfocitos T / Transducción de Señal / Enterotoxinas / Mutación Límite: Animals Idioma: En Revista: J Biol Chem Año: 2018 Tipo del documento: Article

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