A novel allele for inducible Cre expression in germinal center B cells.
Eur J Immunol
; 49(1): 192-194, 2019 01.
Article
en En
| MEDLINE
| ID: mdl-30359469
ABSTRACT
The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP-mediated conditional gene knock-out or knock-in can be used for the genetic manipulation of germinal center B cells in vivo. Here we present a novel allele, Cγ1-CreERT2, that allows for timed activation of Cre recombinase in a small fraction of germinal center B cells. This allele will be useful to study normal and malignant germinal center B cell development in vivo.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfocitos B
/
Centro Germinal
/
Integrasas
/
Técnicas de Sustitución del Gen
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Técnicas de Inactivación de Genes
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Eur J Immunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania