Novel Rhodanine Derivative, 5-[4-(4-Fluorophenoxy) phenyl]methylene-3-{4-[3-(4-methylpiperazin-1-yl) propoxy]phenyl}-2-thioxo-4-thiazolidinone dihydrochloride, Induces Apoptosis via Mitochondria Dysfunction and Endoplasmic Reticulum Stress in Human Colon Cancer Cells.

Jung, Hye-Uk; Lee, Jeong-Hun; Chung, Kyung-Sook; Hong, Joo Young; Choi, Jung-Hye; Kim, Soo-Dong; Roh, Eun Joo; Shin, Kye Jung; Lee, Kyung-Tae

Jung, Hye-Uk; Lee, Jeong-Hun; Chung, Kyung-Sook; Hong, Joo Young; Choi, Jung-Hye; Kim, Soo-Dong; Roh, Eun Joo; Shin, Kye Jung; Lee, Kyung-Tae.

Afiliación

Jung HU; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. 1109jhuk@naver.com.
Lee JH; Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Seoul 130-701, Korea. 1109jhuk@naver.com.
Chung KS; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. ztztzt08@hanmail.net.
Hong JY; Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Seoul 130-701, Korea. ztztzt08@hanmail.net.
Choi JH; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. adella76@hanmail.net.
Kim SD; Department of Pharmaceutical Biochemistry, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. hjisuk1206@naver.com.
Roh EJ; Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Seoul 130-701, Korea. hjisuk1206@naver.com.
Shin KJ; Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Seoul 130-701, Korea. jchoi@khu.ac.kr.
Lee KT; Department of Oriental Pharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea. jchoi@khu.ac.kr.

Molecules ; 23(11)2018 Nov 06.

Article en En | MEDLINE | ID: mdl-30404185

Asunto(s)

Antineoplásicos/química; Apoptosis/efectos de los fármacos; Neoplasias del Colon/metabolismo; Estrés del Retículo Endoplásmico/efectos de los fármacos; Calcio/metabolismo; Línea Celular Tumoral; Retículo Endoplásmico/efectos de los fármacos; Retículo Endoplásmico/metabolismo; Células HCT116; Células HT29; Humanos; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Mitocondrias/efectos de los fármacos; Mitocondrias/metabolismo; Rodanina/química

Palabras clave

ER stress; apoptosis; calcium; colon cancer; mitochondria; rhodanine derivative

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Apoptosis / Neoplasias del Colon / Estrés del Retículo Endoplásmico / Antineoplásicos Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article

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