Photodeamination to quinone methides in cucurbit[n]urils: potential application in drug delivery.
Org Biomol Chem
; 16(46): 8908-8912, 2018 11 28.
Article
en En
| MEDLINE
| ID: mdl-30422137
ABSTRACT
We demonstrate a proof of principle for a new approach in the development of a drug delivery system. A positively charged prodrug (phenol) can form a stable inclusion complex with CB[7], which enables more efficient delivery of the prodrug. After photochemical transformation (photoactivation) inside the complex, an active drug quinone methide (QM) is formed and released from the complex, since it is a neutral molecule and forms a less stable complex with CB[7].
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Hidrocarburos Aromáticos con Puentes
/
Profármacos
/
Fenol
/
Preparaciones de Acción Retardada
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Indolquinonas
/
Imidazoles
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2018
Tipo del documento:
Article
País de afiliación:
Croacia