Expression and functional analysis of flotillins in Dugesia japonica.
Exp Cell Res
; 374(1): 76-84, 2019 01 01.
Article
en En
| MEDLINE
| ID: mdl-30448426
ABSTRACT
FLOTILLIN-1 and FLOTILLIN-2 are membrane rafts associated proteins that have been implicated in insulin and growth factor signaling, endocytosis, cell migration, proliferation, differentiation, cytoskeleton remodeling and membrane trafficking. Furthermore, FLOTILLINs also play important roles in the progression of cancer and neurodegenerative diseases. In this study, the roles of flotillins are investigated in planarian Dugesia japonica. The results show that Djflotillin-1 and Djflotillin-2 play a key role in homeostasis maintenance and regeneration process by regulating the proliferation of the neoblast cells, they are not involved in the maintenance and regeneration of the central nervous system in planarians.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Planarias
/
Proteínas de la Membrana
Límite:
Animals
Idioma:
En
Revista:
Exp Cell Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
China