Structural progression of amyloid-ß Arctic mutant aggregation in cells revealed by multiparametric imaging.

Lu, Meng; Williamson, Neil; Mishra, Ajay; Michel, Claire H; Kaminski, Clemens F; Tunnacliffe, Alan; Kaminski Schierle, Gabriele S

Lu, Meng; Williamson, Neil; Mishra, Ajay; Michel, Claire H; Kaminski, Clemens F; Tunnacliffe, Alan; Kaminski Schierle, Gabriele S.

Afiliación

Lu M; Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United
Williamson N; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.
Mishra A; Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United
Michel CH; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United Kingdom.
Kaminski CF; Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United
Tunnacliffe A; Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom.
Kaminski Schierle GS; Cambridge Infinitus Research Centre, Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge CB3 0AS, United Kingdom; Department of Chemical Engineering and Biotechnology, University of Cambridge, West Cambridge Site, Philippa Fawcett Drive, Cambridge CB3 0AS, United

J Biol Chem ; 294(5): 1478-1487, 2019 02 01.

Article en En | MEDLINE | ID: mdl-30504224

Asunto(s)

Péptidos beta-Amiloides/química; Microscopía Confocal/métodos; Microscopía Fluorescente/métodos; Mutación; Imagen Óptica/métodos; Multimerización de Proteína; Péptidos beta-Amiloides/genética; Péptidos beta-Amiloides/ultraestructura; Humanos; Cinética; Modelos Moleculares; Conformación Proteica

Palabras clave

3D structure of amyloid aggregates; Alzheimer's disease; Arctic mutant; SIM; amyloid-ß; amyloid-ß (Aß); microscopic imaging; molecular dynamics; neurodegeneration; protein aggregation; structural model

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptidos beta-Amiloides / Microscopía Confocal / Multimerización de Proteína / Imagen Óptica / Microscopía Fluorescente / Mutación Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article

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