Matched-pair analysis of survival in the patients with T3 laryngeal squamous cell carcinoma treated with supracricoid partial laryngectomy or total laryngectomy.

Xia, Xin; Zhu, Ying-Ying; Diao, Wen-Wen; Zhu, Xiao-Li; Shi, Xiao-Hua; Li, Wu-Yi; Gao, Zhi-Qiang; Li, Guo-Jun; Chen, Xing-Ming

Xia, Xin; Zhu, Ying-Ying; Diao, Wen-Wen; Zhu, Xiao-Li; Shi, Xiao-Hua; Li, Wu-Yi; Gao, Zhi-Qiang; Li, Guo-Jun; Chen, Xing-Ming.

Afiliación

Xia X; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Zhu YY; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Diao WW; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Zhu XL; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Shi XH; Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Li WY; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Gao ZQ; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Li GJ; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.
Chen XM; Department of Otolaryngology-Head and Neck Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China, xingming.chen@hotmail.com.

Onco Targets Ther ; 11: 7947-7953, 2018.

Article en En | MEDLINE | ID: mdl-30519036

ABSTRACT

ABSTRACT

BACKGROUND:

The survival outcomes between supracricoid partial laryngectomy (SCPL) and total laryngectomy (TL) were compared in the groups of matched-pair patients with T3 laryngeal squamous cell carcinoma (LSCC).

METHODS:

Patients with T3 LSCC were matched based on prognostic factors. The Kaplan-Meier curve and the Cox proportional hazards model were used for analysis on survival.

RESULTS:

A total of 212 patients with T3 LSCC were included after matching (106 underwent SCPL and 106 underwent TL). Multivariable analysis showed no differences in overall survival (hazard risk [HR]=1.15; 95% CI 0.79-1.67; P=0.47), disease-specific survival (HR=1.11; 95% CI 0.69-1.80; P=0.66), and recurrence-free survival (HR=1.07; 95% CI 0.68-1.68; P=0.77) between the SCPL group and TL group.

CONCLUSION:

SCPL provides reliable therapeutic outcomes and can be used to avoid a TL surgery in some patients with advanced primary laryngeal cancer.

Palabras clave

laryngeal neoplasms; laryngectomy; matched-pair analysis; squamous cell carcinoma; survival analysis

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Texto completo: 1 Bases de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Onco Targets Ther Año: 2018 Tipo del documento: Article