Kidney and organoid single-cell transcriptomics: the end of the beginning.
Pediatr Nephrol
; 35(2): 191-197, 2020 02.
Article
en En
| MEDLINE
| ID: mdl-30607565
ABSTRACT
Single-cell RNA sequencing (scRNA-seq) technologies are increasingly being applied to reveal cellular heterogeneity in kidney development and disease. In just the last year, multiple scRNA-seq datasets have been generated from kidney organoids, developing mouse and human kidney, adult kidney, and kidney cancer. The data generated enables a much deeper understanding of biological processes within and between cells. It has also elucidated unforeseen cell lineage relationships, defined the presence of off-target cell types in kidney organoids, and revealed a diverse inflammatory response in a human kidney allograft undergoing rejection. This review summarizes the recent rapid progress in scRNA-seq of the kidney and outlines future directions for single-cell technologies as applied to the kidney.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linaje de la Célula
/
Análisis de la Célula Individual
/
Transcriptoma
/
Riñón
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Pediatr Nephrol
Asunto de la revista:
NEFROLOGIA
/
PEDIATRIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Estados Unidos