Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women.
BMC Infect Dis
; 19(1): 27, 2019 Jan 07.
Article
en En
| MEDLINE
| ID: mdl-30616634
ABSTRACT
BACKGROUND:
Genital warts are important causes of morbidity and their prevalence and incidence can be used to evaluate the impact of HPV vaccination in a population.METHODS:
We enrolled 1020 women in a prospective cohort study in Nigeria and followed them for a mean (SD) of 9 (4) months. Nurses conducted pelvic examinations and collected ectocervical samples for HPV testing. We used exact logistic regression models to identify risk factors for genital warts.RESULTS:
The mean age of study participants was 38 years, 56% (535/962) were HIV-negative and 44% (427/962) were HIV-positive. Prevalence of genital warts at enrolment was 1% (4/535) among HIV-negative women, and 5% (23/427) among HIV-positive women. Of 614 women (307 HIV negative and 307 HIV positive women) for whom we could compute genital wart incidence, it was 515 (95% CI13-2872) per 100,000 person-years in HIV-negative and 1370 (95% CI283-4033) per 100,000 person-years in HIV-positive women. HIV was associated with higher risk of prevalent genital warts (OR7.14, 95% CI2.41-28.7, p < 0.001) while higher number of sex partners in the past year was associated with increased risk of incident genital warts (OR2.86, 95% CI1.04-6.47. p = 0.04). HPV11 was the only HPV associated with prevalent genital warts in this population (OR8.21, 95% CI2.47-27.3, p = 0.001).CONCLUSION:
Genital warts are common in Nigeria and our results provide important parameters for monitoring the impact of future HPV vaccination programs in the country. HIV infection and number of sexual partners in past year were important risk factors for prevalent and incident genital warts respectively.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Condiloma Acuminado
/
Infecciones por Papillomavirus
Tipo de estudio:
Etiology_studies
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Incidence_studies
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Observational_studies
/
Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
País/Región como asunto:
Africa
Idioma:
En
Revista:
BMC Infect Dis
Asunto de la revista:
DOENCAS TRANSMISSIVEIS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido