Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.

Ebstein, Sarah Y; Yagudayeva, Ilona; Shneider, Neil A

Ebstein, Sarah Y; Yagudayeva, Ilona; Shneider, Neil A.

Afiliación

Ebstein SY; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, 630 W 168th Street, P&S Building, Room 5-423, New York, NY 10032, USA.
Yagudayeva I; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, 630 W 168th Street, P&S Building, Room 5-423, New York, NY 10032, USA.
Shneider NA; Department of Neurology, Center for Motor Neuron Biology and Disease, Columbia University Irving Medical Center, 630 W 168th Street, P&S Building, Room 5-423, New York, NY 10032, USA; Eleanor and Lou Gehrig ALS Center, Columbia University Irving Medical Center, 630 W 168th Street, P&S Building, Room 5-423, New York, NY 10032, USA. Electronic address: ns327@columbia.edu.

Cell Rep ; 26(2): 364-373.e4, 2019 01 08.

Article en En | MEDLINE | ID: mdl-30625319

Asunto(s)

Esclerosis Amiotrófica Lateral/genética; Proteínas de Unión al ADN/genética; Neuronas Motoras/patología; Esclerosis Amiotrófica Lateral/metabolismo; Esclerosis Amiotrófica Lateral/patología; Animales; Femenino; Gliosis; Masculino; Ratones; Ratones Endogámicos C57BL; Neuronas Motoras/metabolismo; Mutación; Penetrancia

Palabras clave

TARDBP; TDP-43; amyotrophic lateral sclerosis; knockin mouse; motor neuron disease; muscle denervation; neurodegeneration

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas de Unión al ADN / Esclerosis Amiotrófica Lateral / Neuronas Motoras Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Cell Rep Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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