The failing heart utilizes 3-hydroxybutyrate as a metabolic stress defense.
JCI Insight
; 4(4)2019 02 21.
Article
en En
| MEDLINE
| ID: mdl-30668551
ABSTRACT
Evidence has emerged that the failing heart increases utilization of ketone bodies. We sought to determine whether this fuel shift is adaptive. Mice rendered incapable of oxidizing the ketone body 3-hydroxybutyrate (3OHB) in the heart exhibited worsened heart failure in response to fasting or a pressure overload/ischemic insult compared with WT controls. Increased delivery of 3OHB ameliorated pathologic cardiac remodeling and dysfunction in mice and in a canine pacing model of progressive heart failure. 3OHB was shown to enhance bioenergetic thermodynamics of isolated mitochondria in the context of limiting levels of fatty acids. These results indicate that the heart utilizes 3OHB as a metabolic stress defense and suggest that strategies aimed at increasing ketone delivery to the heart could prove useful in the treatment of heart failure.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Ácido 3-Hidroxibutírico
/
Metabolismo Energético
/
Insuficiencia Cardíaca
/
Ventrículos Cardíacos
/
Miocardio
Tipo de estudio:
Etiology_studies
Límite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
JCI Insight
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos