Cyclooctatetraene: A Bioactive Cubane Paradigm Complement.
Chemistry
; 25(11): 2729-2734, 2019 Feb 21.
Article
en En
| MEDLINE
| ID: mdl-30681236
ABSTRACT
Cubane was recently validated as a phenyl ring (bio)isostere, but highly strained caged carbocyclic systems lack π character, which is often critical for mediating key biological interactions. This electronic property restriction associated with cubane has been addressed herein with cyclooctatetraene (COT), using known pharmaceutical and agrochemical compounds as templates. COT either outperformed or matched cubane in multiple cases suggesting that versatile complementarity exists between the two systems for enhanced bioactive molecule discovery.
Texto completo:
1
Bases de datos:
MEDLINE
País/Región como asunto:
Cuba
Idioma:
En
Revista:
Chemistry
Asunto de la revista:
QUIMICA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia