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Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms.
Jones, Samuel E; Lane, Jacqueline M; Wood, Andrew R; van Hees, Vincent T; Tyrrell, Jessica; Beaumont, Robin N; Jeffries, Aaron R; Dashti, Hassan S; Hillsdon, Melvyn; Ruth, Katherine S; Tuke, Marcus A; Yaghootkar, Hanieh; Sharp, Seth A; Jie, Yingjie; Thompson, William D; Harrison, Jamie W; Dawes, Amy; Byrne, Enda M; Tiemeier, Henning; Allebrandt, Karla V; Bowden, Jack; Ray, David W; Freathy, Rachel M; Murray, Anna; Mazzotti, Diego R; Gehrman, Philip R; Lawlor, Debbie A; Frayling, Timothy M; Rutter, Martin K; Hinds, David A; Saxena, Richa; Weedon, Michael N.
Afiliación
  • Jones SE; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Lane JM; Center for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, MA, USA.
  • Wood AR; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, 02114, MA, USA.
  • van Hees VT; Broad Institute, Cambridge, 02142, MA, USA.
  • Tyrrell J; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Beaumont RN; Netherlands eScience Center, Amsterdam, 1098, XG, Netherlands.
  • Jeffries AR; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Dashti HS; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Hillsdon M; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Ruth KS; Center for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, MA, USA.
  • Tuke MA; Broad Institute, Cambridge, 02142, MA, USA.
  • Yaghootkar H; Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX1 2LU, UK.
  • Sharp SA; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Jie Y; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Thompson WD; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Harrison JW; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Dawes A; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Byrne EM; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Tiemeier H; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Allebrandt KV; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Bowden J; The University of Queensland, Institute for Molecular Bioscience, Brisbane, 4072, QLD, Australia.
  • Ray DW; Department of Epidemiology, Erasmus Medical Center, Rotterdam, 3015, GE, Netherlands.
  • Freathy RM; Department of Psychiatry, Erasmus Medical Center, Rotterdam, 3015, GD, Netherlands.
  • Murray A; Department of Translational Informatics, Translational Medicine Early Development, Sanofi-Aventis Deutschland GmbH, Industriepark Höchst, Frankfurt, 65926, Germany.
  • Mazzotti DR; MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, BS8 2BN, UK.
  • Gehrman PR; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 2BN, UK.
  • Lawlor DA; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.
  • Frayling TM; Division of Endocrinology, Diabetes & Gastroenterology, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, M13 9PL, UK.
  • Rutter MK; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Hinds DA; Genetics of Complex Traits, University of Exeter Medical School, Royal Devon & Exeter Hospital, Exeter, EX2 5DW, UK.
  • Saxena R; Center for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
  • Weedon MN; Perelman School of Medicine of the University of Pennsylvania, Philadelphia, 19104, PA, USA.
Nat Commun ; 10(1): 343, 2019 01 29.
Article en En | MEDLINE | ID: mdl-30696823
ABSTRACT
Being a morning person is a behavioural indicator of a person's underlying circadian rhythm. Using genome-wide data from 697,828 UK Biobank and 23andMe participants we increase the number of genetic loci associated with being a morning person from 24 to 351. Using data from 85,760 individuals with activity-monitor derived measures of sleep timing we find that the chronotype loci associate with sleep timing the mean sleep timing of the 5% of individuals carrying the most morningness alleles is 25 min earlier than the 5% carrying the fewest. The loci are enriched for genes involved in circadian regulation, cAMP, glutamate and insulin signalling pathways, and those expressed in the retina, hindbrain, hypothalamus, and pituitary. Using Mendelian Randomisation, we show that being a morning person is causally associated with better mental health but does not affect BMI or risk of Type 2 diabetes. This study offers insights into circadian biology and its links to disease in humans.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ritmo Circadiano / Población Blanca / Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Ritmo Circadiano / Población Blanca / Estudio de Asociación del Genoma Completo Tipo de estudio: Clinical_trials / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Nat Commun Asunto de la revista: BIOLOGIA / CIENCIA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido