Tropomyosins: Potential Biomarkers for Urothelial Bladder Cancer.
Int J Mol Sci
; 20(5)2019 Mar 04.
Article
en En
| MEDLINE
| ID: mdl-30836651
ABSTRACT
Despite the incidence and prevalence of urothelial bladder cancer (UBC), few advances in treatment and diagnosis have been made in recent years. In this review, we discuss potential biomarker candidates the tropomyosin family of genes, encoded by four loci in the human genome. The expression of these genes is tissue-specific. Tropomyosins are responsible for diverse cellular roles, most notably based upon their interplay with actin to maintain cellular processes, integrity and structure. Tropomyosins exhibit a large variety of splice forms, and altered isoform expression levels have been associated with cancer, including UBC. Notably, tropomyosin isoforms are detectable in urine, offering the potential for non-invasive diagnosis and risk-stratification. This review collates the basic knowledge on tropomyosin and its isoforms, and discusses their relationships with cancer-related phenomena, most specifically in UBC.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Tropomiosina
/
Neoplasias de la Vejiga Urinaria
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Biomarcadores de Tumor
/
Familia de Multigenes
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Int J Mol Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Reino Unido