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Surgery for cholangiocarcinoma.
Cillo, Umberto; Fondevila, Constantino; Donadon, Matteo; Gringeri, Enrico; Mocchegiani, Federico; Schlitt, Hans J; Ijzermans, Jan N M; Vivarelli, Marco; Zieniewicz, Krzysztof; Olde Damink, Steven W M; Groot Koerkamp, Bas.
Afiliación
  • Cillo U; Department of Surgery, Oncology and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation Unit, Padova University Hospital, Padova, Italy.
  • Fondevila C; Department of General & Digestive Surgery, Institut de Malalties Digestives I Metabòliques (IMDiM), Hospital Clínic, University of Barcelona, Spain.
  • Donadon M; Department of Surgery, Division of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, Humanitas University, Rozzano, Italy.
  • Gringeri E; Department of Surgery, Oncology and Gastroenterology, Hepatobiliary Surgery and Liver Transplantation Unit, Padova University Hospital, Padova, Italy.
  • Mocchegiani F; Hepatopancreatobiliary and Transplant Unit, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.
  • Schlitt HJ; Department of Surgery, University Hospital Regensburg, Regensburg, Germany.
  • Ijzermans JNM; Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
  • Vivarelli M; Hepatopancreatobiliary and Transplant Unit, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Ancona, Italy.
  • Zieniewicz K; Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Warsaw, Poland.
  • Olde Damink SWM; Department of Surgery, Maastricht University Medical Center, Maastricht, The Netherlands.
  • Groot Koerkamp B; Department of General, Visceral and Transplantation Surgery, RWTH University Hospital Aachen, Aachen, Germany.
Liver Int ; 39 Suppl 1: 143-155, 2019 05.
Article en En | MEDLINE | ID: mdl-30843343
Surgical resection is the only potentially curative treatment for patients with cholangiocarcinoma. For both perihilar cholangiocarcinoma (pCCA) and intrahepatic cholangiocarcinoma (iCCA), 5-year overall survival of about 30% has been reported in large series. This review addresses several challenges in surgical management of cholangiocarcinoma. The first challenge is diagnosis: a biopsy is typically avoided because of the risk of seeding metastases and the low yield of a brush of the bile duct. However, about 15% of patients with suspected pCCA are found to have a benign diagnosis after resection. The second challenge is staging; even with the best preoperative imaging, a substantial percentage of patients has occult metastatic disease detected at staging laparoscopy or early recurrence after resection. The third challenge is an adequate volume and function of the future liver remnant, which may require preoperative biliary drainage and portal vein embolization. The fourth challenge is a complete resection: a positive bile duct margin is not uncommon because the microscopic biliary extent of disease may be more extensive than perceived on imaging. The fifth challenge is the high post-operative mortality that has decreased in very high volume Asian centres, but remains about 10% in many Western referral centres. The sixth challenge is that even after a complete resection most patients develop recurrent disease. Recent randomized controlled trials found conflicting results regarding the benefit of adjuvant chemotherapy. The final challenge is to determine which patients with cholangiocarcinoma should undergo liver transplantation rather than resection.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Trasplante de Hígado / Colangiocarcinoma / Hepatectomía / Escisión del Ganglio Linfático Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias de los Conductos Biliares / Trasplante de Hígado / Colangiocarcinoma / Hepatectomía / Escisión del Ganglio Linfático Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Liver Int Asunto de la revista: GASTROENTEROLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia