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Anti-alcohol abuse drug disulfiram inhibits human PHGDH via disruption of its active tetrameric form through a specific cysteine oxidation.
Spillier, Quentin; Vertommen, Didier; Ravez, Séverine; Marteau, Romain; Thémans, Quentin; Corbet, Cyril; Feron, Olivier; Wouters, Johan; Frédérick, Raphaël.
Afiliación
  • Spillier Q; Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium.
  • Vertommen D; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium.
  • Ravez S; de Duve Institute, Université catholique de Louvain, B-1200, Brussels, Belgium.
  • Marteau R; UMR-S1172 - JPArc - Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer, Université de Lille, Inserm, CHU Lille, F-59000, Lille, France.
  • Thémans Q; Medicinal Chemistry Research Group (CMFA), Louvain Drug Research Institute (LDRI), Université Catholique de Louvain, B-1200, Brussels, Belgium.
  • Corbet C; Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), Université de Namur, 61 rue de Bruxelles, B-5000, Namur, Belgium.
  • Feron O; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium.
  • Wouters J; Pole of Pharmacology and Therapeutics (FATH), Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain, B-1200, Brussels, Belgium.
  • Frédérick R; Department of Chemistry, NAmur MEdicine & Drug Innovation Center (NAMEDIC-NARILIS), Université de Namur, 61 rue de Bruxelles, B-5000, Namur, Belgium.
Sci Rep ; 9(1): 4737, 2019 03 18.
Article en En | MEDLINE | ID: mdl-30894617
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cisteína / Disulfiram / Fosfoglicerato-Deshidrogenasa / Multimerización de Proteína / Antineoplásicos Límite: Humans Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Bélgica
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Cisteína / Disulfiram / Fosfoglicerato-Deshidrogenasa / Multimerización de Proteína / Antineoplásicos Límite: Humans Idioma: En Revista: Sci Rep Año: 2019 Tipo del documento: Article País de afiliación: Bélgica