Global Genetic Networks and the Genotype-to-Phenotype Relationship.
Cell
; 177(1): 85-100, 2019 03 21.
Article
en En
| MEDLINE
| ID: mdl-30901552
Genetic interactions identify combinations of genetic variants that impinge on phenotype. With whole-genome sequence information available for thousands of individuals within a species, a major outstanding issue concerns the interpretation of allelic combinations of genes underlying inherited traits. In this Review, we discuss how large-scale analyses in model systems have illuminated the general principles and phenotypic impact of genetic interactions. We focus on studies in budding yeast, including the mapping of a global genetic network. We emphasize how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Redes Reguladoras de Genes
/
Estudios de Asociación Genética
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
2019
Tipo del documento:
Article