Enzymatic interconversion of the oxysterols 7ß,25-dihydroxycholesterol and 7-keto,25-hydroxycholesterol by 11ß-hydroxysteroid dehydrogenase type 1 and 2.

Beck, Katharina R; Kanagaratnam, Sharavan; Kratschmar, Denise V; Birk, Julia; Yamaguchi, Hideaki; Sailer, Andreas W; Seuwen, Klaus; Odermatt, Alex

Beck, Katharina R; Kanagaratnam, Sharavan; Kratschmar, Denise V; Birk, Julia; Yamaguchi, Hideaki; Sailer, Andreas W; Seuwen, Klaus; Odermatt, Alex.

Afiliación

Beck KR; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Kanagaratnam S; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Kratschmar DV; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Birk J; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland.
Yamaguchi H; Department of Applied Biological Chemistry, Meijo University, Nagoya 468-8502, Japan.
Sailer AW; Disease Area X, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Seuwen K; Disease Area X, Novartis Institutes for BioMedical Research, Basel, Switzerland.
Odermatt A; Division of Molecular and Systems Toxicology, Department of Pharmaceutical Sciences, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: Alex.Odermatt@unibas.ch.

J Steroid Biochem Mol Biol ; 190: 19-28, 2019 06.

Article en En | MEDLINE | ID: mdl-30902677

Asunto(s)

11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/metabolismo; 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2/metabolismo; Hidroxicolesteroles/metabolismo; Cetocolesteroles/metabolismo; Animales; Células HEK293; Humanos; Hidroxilación; Ratones; Ratones Endogámicos C57BL; Simulación del Acoplamiento Molecular; Oxidación-Reducción; Células RAW 264.7

Palabras clave

11beta-hydroxysteroid dehydrogenase; 7-ketocholesterol; Cholesterol 25-hydroxylase; Epstein-Barr virus-induced gene 2; Metabolism; Oxysterol

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1 / 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 2 / Hidroxicolesteroles / Cetocolesteroles Límite: Animals / Humans Idioma: En Revista: J Steroid Biochem Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Suiza

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