Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Baffi, Timothy R; Van, An-Angela N; Zhao, Wei; Mills, Gordon B; Newton, Alexandra C

Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.

Baffi, Timothy R; Van, An-Angela N; Zhao, Wei; Mills, Gordon B; Newton, Alexandra C.

Afiliación

Baffi TR; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.
Van AN; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA; Biomedical Sciences Graduate Program, University of California at San Diego, La Jolla, CA 92093, USA.
Zhao W; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Newton AC; Department of Pharmacology, University of California at San Diego, La Jolla, CA 92093, USA. Electronic address: anewton@ucsd.edu.

Mol Cell ; 74(2): 378-392.e5, 2019 04 18.

Article en En | MEDLINE | ID: mdl-30904392

Asunto(s)

Neoplasias/genética; Proteínas Nucleares/genética; Fosfoproteínas Fosfatasas/genética; Proteína Quinasa C beta/genética; Proteína Quinasa C-alfa/genética; Humanos; Isoenzimas/genética; Mutación con Pérdida de Función/genética; Neoplasias/patología; Fosforilación; Proteolisis; Proteínas Proto-Oncogénicas c-akt/genética; Control de Calidad; Transducción de Señal/genética

Palabras clave

PHLPP1; autoinhibition; cancer; degradation; loss of function; pancreatic cancer; phosphorylation; protein kinase C; quality control; reverse phase protein array

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Nucleares / Fosfoproteínas Fosfatasas / Proteína Quinasa C-alfa / Proteína Quinasa C beta / Neoplasias Límite: Humans Idioma: En Revista: Mol Cell Asunto de la revista: BIOLOGIA MOLECULAR Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos

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