Pinacidil, a KATP channel opener, stimulates cardiac Na<sup>+</sup>/Ca<sup>2+</sup> exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes.

Iguchi, Keisuke; Saotome, Masao; Yamashita, Kanna; Hasan, Prottoy; Sasaki, Miyuki; Maekawa, Yuichiro; Watanabe, Yasuhide

Pinacidil, a KATP channel opener, stimulates cardiac Na⁺/Ca²⁺ exchanger function through the NO/cGMP/PKG signaling pathway in guinea pig cardiac ventricular myocytes.

Iguchi, Keisuke; Saotome, Masao; Yamashita, Kanna; Hasan, Prottoy; Sasaki, Miyuki; Maekawa, Yuichiro; Watanabe, Yasuhide.

Afiliación

Iguchi K; Department of Internal Medicine III (Cardiology), Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Saotome M; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
Yamashita K; Department of Internal Medicine III (Cardiology), Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Hasan P; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
Sasaki M; Department of Internal Medicine III (Cardiology), Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.
Maekawa Y; Division of Pharmacological Science, Department of Health Science, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu, 431-3192, Japan.
Watanabe Y; Department of Internal Medicine III (Cardiology), Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan.

Naunyn Schmiedebergs Arch Pharmacol ; 392(8): 949-959, 2019 08.

Article en En | MEDLINE | ID: mdl-30919008

Asunto(s)

Proteínas Quinasas Dependientes de GMP Cíclico; GMP Cíclico; Canales KATP/agonistas; Miocitos Cardíacos/efectos de los fármacos; Óxido Nítrico; Pinacidilo/farmacología; Transducción de Señal/efectos de los fármacos; Intercambiador de Sodio-Calcio/metabolismo; Animales; Antioxidantes/farmacología; Cobayas; Ventrículos Cardíacos/citología; Ventrículos Cardíacos/metabolismo; Miocitos Cardíacos/metabolismo; Técnicas de Placa-Clamp; Pinacidilo/antagonistas & inhibidores; Estimulación Química

Palabras clave

Cardiac myocytes; Na+/Ca2+ exchange current (INCX); Nonselective KATP channel opener; Patch-clamp technique; Pinacidil

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Transducción de Señal / Proteínas Quinasas Dependientes de GMP Cíclico / GMP Cíclico / Intercambiador de Sodio-Calcio / Pinacidilo / Miocitos Cardíacos / Canales KATP / Óxido Nítrico Límite: Animals Idioma: En Revista: Naunyn Schmiedebergs Arch Pharmacol Año: 2019 Tipo del documento: Article País de afiliación: Japón

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google