Depot formulations to sustain periocular drug delivery to the posterior eye segment.
Drug Discov Today
; 24(8): 1458-1469, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-30930148
ABSTRACT
The periocular space is a promising alternative route for the delivery of drugs to the posterior eye segment, especially when treating conditions in the outer ocular layers. In this review, we discuss the different periocular routes as well as the physiological barriers and elimination mechanisms limiting drug bioavailability at the back of the eye. We then highlight various types of depot formulations, including particulate delivery systems, semisolid formulations, and implants, used to increase the contact time with the ocular tissues. With the additional advantage of sustaining drug release, such depot formulations could enhance periocular drug delivery to the posterior eye segment.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Preparaciones de Acción Retardada
/
Oftalmopatías
/
Segmento Posterior del Ojo
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Drug Discov Today
Asunto de la revista:
FARMACOLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
2019
Tipo del documento:
Article
País de afiliación:
Nueva Zelanda