Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group.
J Geriatr Oncol
; 11(1): 62-68, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-30940492
ABSTRACT
INTRODUCTION:
Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups.METHODS:
We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60â¯years old from Thailand nationwide multicenter registry.RESULTS:
Of 127 patients, median age of diagnosis was 67â¯years old. Patients aged older than 75â¯years old had similar characteristics to younger (60-74â¯years old) but higher comorbidity index. Seventy-nine patients (62.2%) received intensive/definite multi-agent chemotherapy, however, the proportion was significant lower in older patients (70.4% vs 34.5%, pâ¯<â¯.001). After a median follow up duration of 17.3â¯months, 2-year progression free survival and overall survival were 38.1% and 48.5%. Univariate and multivariable analysis demonstrated older age, poor performance status and absence of definite multi-agent chemotherapy were associated with inferior survival. Definite multi-agent lymphoma specific chemotherapy was an independent factor for overall survival after adjustment for age, comorbidity index, performance status and prognostic index for T cell lymphoma.CONCLUSION:
Despite overall poor prognosis of PTCL and NKTCL in older adults, chemotherapy could result in objective response and long-term survival in selected patients of this vulnerable age group thus emphasizing the importance of comprehensive geriatric evaluation.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Linfoma de Células T
/
Linfoma de Células T Periférico
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
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Humans
País/Región como asunto:
Asia
Idioma:
En
Revista:
J Geriatr Oncol
Año:
2020
Tipo del documento:
Article