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Bedaquiline overdose: A case report.
Telnov, Oleksandr; Alvarez, Veronica; Graglia, Elena; Molfino, Lucas; du Cros, Philipp; Rich, Michael.
Afiliación
  • Telnov O; Médecins Sans Frontières Switzerland, Geneva, Switzerland. Electronic address: alex.telnov@geneva.msf.org.
  • Alvarez V; Médecins Sans Frontières Switzerland, Geneva, Switzerland.
  • Graglia E; Médecins Sans Frontières Switzerland, Geneva, Switzerland.
  • Molfino L; Médecins Sans Frontières Switzerland, Geneva, Switzerland.
  • du Cros P; Manson Unit, Médecins Sans Frontières UK, London, UK; Burnet Institute, Melbourne, Australia.
  • Rich M; Brigham and Women's Hospital, Boston, MA, USA.
Int J Infect Dis ; 84: 138-140, 2019 Jul.
Article en En | MEDLINE | ID: mdl-30951878
We present a case report describing outcomes in a 21 year old HIV-negative man who received treatment with bedaquiline. Due to error, dosage received comprised 4 pills of 100 mg every second day in the 60 days following the first two weeks of 4 pills of 100 mg every day. On detection, treatment was continued as per standard dosing of 200 mg given three times per week, with enhanced monitoring of ECG and liver function. The man was asymptomatic, with no signs of jaundice, abdominal pain, or abnormal heart rhythm. Toxic effects at this dosage were therefore not observed.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sobredosis de Droga / Diarilquinolinas / Antituberculosos Límite: Adult / Humans / Male Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Sobredosis de Droga / Diarilquinolinas / Antituberculosos Límite: Adult / Humans / Male Idioma: En Revista: Int J Infect Dis Asunto de la revista: DOENCAS TRANSMISSIVEIS Año: 2019 Tipo del documento: Article