Serum cytokine and chemokine changes during Toscana virus meningitis.
Med Microbiol Immunol
; 208(6): 727-730, 2019 Dec.
Article
en En
| MEDLINE
| ID: mdl-30976912
Toscana virus is an important arbovirus causing meningitis and meningoencephalitis in countries around the Mediterranean Sea. While the clinical syndrome and laboratory diagnostic procedures have been well described, less is known about the immune response in Toscana virus meningitis and a possible use of cytokine and chemokine changes for the clinical follow-up of patients. We here characterized serum cytokine and chemokine profiles from 37 patients during the acute and convalescent phase of the infection. Only few serum cytokine/chemokine changes were detected during Toscana virus meningitis. Markedly increased concentrations of IP-10, interferon-α, IL-22, and eotaxin were found in the acute phase. Levels of interferon-α, IL-22, and eotaxin remained elevated in the convalescent phase, but decreased concentrations of GM-CSF were detected.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Citocinas
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Fiebre por Flebótomos
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Virus de Nápoles de la Fiebre de la Mosca de los Arenales
/
Suero
/
Meningitis Viral
Tipo de estudio:
Observational_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Revista:
Med Microbiol Immunol
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania