High-resolution genomic alterations in Barrett's metaplasia of patients who progress to esophageal dysplasia and adenocarcinoma.

Sepulveda, Jorge L; Komissarova, Elena V; Kongkarnka, Sarawut; Friedman, Richard A; Davison, Jon M; Levy, Brynn; Bryk, Diana; Jobanputra, Vaidehi; Del Portillo, Armando; Falk, Gary W; Sonett, Joshua R; Lightdale, Charles J; Abrams, Julian A; Wang, Timothy C; Sepulveda, Antonia R

Sepulveda, Jorge L; Komissarova, Elena V; Kongkarnka, Sarawut; Friedman, Richard A; Davison, Jon M; Levy, Brynn; Bryk, Diana; Jobanputra, Vaidehi; Del Portillo, Armando; Falk, Gary W; Sonett, Joshua R; Lightdale, Charles J; Abrams, Julian A; Wang, Timothy C; Sepulveda, Antonia R.

Afiliación

Sepulveda JL; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Komissarova EV; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Kongkarnka S; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Friedman RA; Biomedical Informatics Shared Resource, Herbert Irving Comprehensive Cancer Center and Department of Biomedical Informatics, CUIMC, New York, NY.
Davison JM; Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Levy B; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Bryk D; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Jobanputra V; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Del Portillo A; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.
Falk GW; Division of Gastroenterology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
Sonett JR; Division of Thoracic Surgery, Department of Surgery, CUIMC, New York, NY.
Lightdale CJ; Division of Digestive and Liver Diseases, Department of Medicine, CUIMC, New York, NY.
Abrams JA; Division of Digestive and Liver Diseases, Department of Medicine, CUIMC, New York, NY.
Wang TC; Division of Digestive and Liver Diseases, Department of Medicine, CUIMC, New York, NY.
Sepulveda AR; Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY.

Int J Cancer ; 145(10): 2754-2766, 2019 11 15.

Article en En | MEDLINE | ID: mdl-31001805

Asunto(s)

Adenocarcinoma/patología; Esófago de Barrett/genética; Biomarcadores de Tumor/genética; Mucosa Esofágica/patología; Neoplasias Esofágicas/patología; Lesiones Precancerosas/genética; Ácido Anhídrido Hidrolasas/genética; Adulto; Anciano; Esófago de Barrett/patología; Inhibidor p15 de las Quinasas Dependientes de la Ciclina/genética; Inhibidor p16 de la Quinasa Dependiente de Ciclina/genética; Variaciones en el Número de Copia de ADN; Progresión de la Enfermedad; Exones/genética; Femenino; Humanos; Hibridación Fluorescente in Situ; Estudios Longitudinales; Masculino; Persona de Mediana Edad; Proteínas de Neoplasias/genética; Polimorfismo de Nucleótido Simple; Lesiones Precancerosas/patología; Proteína p53 Supresora de Tumor/genética

Palabras clave

Barrett esophagus/*diagnosis/genetics; OncoScan array; adenocarcinoma/*diagnosis/genetics; biomarkers; carcinogenesis/*genetics; disease progression; esophageal neoplasms/*genetics/pathology; molecular inversion probes assay; paraffin embedding/*methods; somatic copy number aberrations; tumor/analysis/genetics

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Lesiones Precancerosas / Esófago de Barrett / Neoplasias Esofágicas / Adenocarcinoma / Biomarcadores de Tumor / Mucosa Esofágica Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Int J Cancer Año: 2019 Tipo del documento: Article

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