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3D Printed scaffolds with hierarchical biomimetic structure for osteochondral regeneration.
Zhou, Xuan; Esworthy, Timothy; Lee, Se-Jun; Miao, Shida; Cui, Haitao; Plesiniak, Michael; Fenniri, Hicham; Webster, Thomas; Rao, Raj D; Zhang, Lijie Grace.
Afiliación
  • Zhou X; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
  • Esworthy T; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
  • Lee SJ; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
  • Miao S; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
  • Cui H; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA.
  • Plesiniak M; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC, USA.
  • Fenniri H; Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
  • Webster T; Department of Chemical Engineering, Northeastern University, Boston, MA, USA.
  • Rao RD; Department of Orthopedic Surgery, The George Washington University, Washington, DC, USA.
  • Zhang LG; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC, USA; Department of Biomedical Engineering, The George Washington University, Washington, DC, USA; Department of Electrical and Computer Engineering, The George Washington University, Washington, DC,
Nanomedicine ; 19: 58-70, 2019 07.
Article en En | MEDLINE | ID: mdl-31004813
ABSTRACT
Osteochondral defects resulting from trauma and/or pathologic disorders are critical clinical problems. The current approaches still do not yield satisfactory due to insufficient donor sources and potential immunological rejection of implanted tissues. 3D printing technology has shown great promise for fabricating customizable, biomimetic tissue matrices. The purpose of the present study is to investigate 3D printed scaffolds with biomimetic, biphasic structure for osteochondral regeneration. For this purpose, nano-hydroxyapatite and transforming growth factor beta 1 nanoparticles were synthesized and distributed separately into the lower and upper layers of the biphasic scaffold, which was fabricated using 3D stereolithography printer. Our results showed that this scaffold design successfully promoted osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells, as well as enhanced gene expression associated with both osteogenesis and chondrogenesis alike. The finding demonstrated that 3D printed osteochondral scaffolds with biomimetic, biphasic structure are excellent candidates for osteochondral repair and regeneration.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteogénesis / Regeneración / Condrogénesis / Materiales Biomiméticos / Andamios del Tejido / Impresión Tridimensional Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Osteogénesis / Regeneración / Condrogénesis / Materiales Biomiméticos / Andamios del Tejido / Impresión Tridimensional Límite: Humans Idioma: En Revista: Nanomedicine Asunto de la revista: BIOTECNOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos