The short-term and long-term outcome of febrile infection-related epilepsy syndrome in children.
Epilepsy Behav
; 95: 117-123, 2019 06.
Article
en En
| MEDLINE
| ID: mdl-31035103
ABSTRACT
BACKGROUND:
The febrile infection-related epilepsy syndrome (FIRES) is a catastrophic epileptic encephalopathy which developed the refractory status epilepticus following or during a nonspecific febrile illness. To analyze the short-term and long-term outcome of FIRES in the children, we retrospectively analyzed the related data.METHODS:
The motor outcome was evaluated by modified Rankin scale (mRS). Poor motor outcome was defined as a mRS score of 4 or higher at discharge. Significant motor decline was defined as the mRS difference more than 2 before hospital admission and at discharge.RESULTS:
We totally enrolled 25 patients for analysis. Four patients were expired during hospitalization, and one patient was lost to follow-up after discharge. Therefore, a total 20 patients were finally analyzed. The age of disease onset ranged from 1.6 to 17.2â¯years (mean 9.6⯱â¯4.4â¯years). Newly acquired epilepsy and cognitive deficit occurred in 100% and 61%, respectively. The duration of the anesthetic agents ranged from 7 to 149â¯days (mean 34.2⯱â¯36.1â¯days). The duration of anesthetic agent usage (pâ¯=â¯0.011), refractory epilepsy (pâ¯=â¯0.003), and the use of ketogenic diet (pâ¯=â¯0.004) were significantly associated with the poor long-term motor outcome, and the number of anesthetic agents tended to be associated with the poor long-term motor outcome (pâ¯=â¯0.050). In-hospital mortality was 16%. Significant functional decline at discharge occurred in 100%. However, there was improvement in long-term follow-up.CONCLUSION:
The outcome of FIRES is poor with significant mortality and morbidities. Refractory epilepsy with cognitive deficit in survived cases is common, but improvement is possible.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Estado Epiléptico
/
Convulsiones Febriles
/
Dieta Cetogénica
/
Disfunción Cognitiva
/
Epilepsia Refractaria
/
Trastornos Motores
/
Anestésicos
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Epilepsy Behav
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Taiwán