Adaptations to a Generalized Radiation Dose Reconstruction Methodology for Use in Epidemiologic Studies: An Update from the MD Anderson Late Effect Group.
Radiat Res
; 192(2): 169-188, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31211642
ABSTRACT
Epidemiologic studies that include patients who underwent radiation therapy for the treatment of cancer aim to quantify the relationship between radiotherapy and the risk of subsequent late effects. Because of the long follow-up period required to observe late effects, these studies are conducted retrospectively. The studies routinely include patients treated across numerous institutions using a wide range of technologies and represent treatments over several decades. As a result, determining the dose throughout the patient's body is uniquely challenging. Therefore, estimating doses throughout the patient's body for epidemiologic studies requires special methodologies that are generally applied to a wide range of radiotherapy techniques. Over ten years ago, the MD Anderson Late Effects Group described various dose reconstruction methods for therapeutic and diagnostic radiation exposure for epidemiologic studies. Here we provide an update to the most widely used dose reconstruction methodology for epidemiologic studies, analytical model calculations combined with a 3D age-specific computational phantom. In particular, we describe the various adaptations (and enhancements) of that methodology, as well as how they have been used in radiation epidemiology studies and may be used in future studies.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Dosis de Radiación
/
Estudios Epidemiológicos
/
Exposición a la Radiación
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Revista:
Radiat Res
Año:
2019
Tipo del documento:
Article