Connecting Versatile lncRNAs with Heterogeneous Nuclear Ribonucleoprotein K and Pathogenic Disorders.
Trends Biochem Sci
; 44(9): 733-736, 2019 09.
Article
en En
| MEDLINE
| ID: mdl-31279651
ABSTRACT
Heterogeneous nuclear ribonucleoprotein K (hnRNPK) is an RNA-binding protein that regulates multiple biological processes, including paraspeckles formation and cellular signal transduction. Recently, hnRNPK has been shown to interact with SINE-derived nuclear RNA localization (SIRLOIN)-containing RNAs, and orchestrate nuclear enrichment and cellular functions of long noncoding RNAs (lncRNAs). hnRNPK-lncRNAs interaction is potentially implicated in various pathogenic disorders including tumorigenesis, and Kabuki-like, Au-Kline, and Okamoto syndromes.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Síndromes Paraneoplásicos
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Fisura del Paladar
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Ribonucleoproteína Heterogénea-Nuclear Grupo K
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ARN Largo no Codificante
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Hidronefrosis
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Discapacidad Intelectual
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Hipotonía Muscular
Límite:
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2019
Tipo del documento:
Article
País de afiliación:
Australia