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Prevalence survey of healthcare-associated infections in a large teaching hospital.
Barbato, D; Castellani, F; Angelozzi, A; Isonne, C; Baccolini, V; Migliara, G; Marzuillo, C; De Vito, C; Villari, P; Romano, F; De Giusti, M.
Afiliación
  • Barbato D; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Castellani F; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Angelozzi A; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Isonne C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Baccolini V; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Migliara G; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Marzuillo C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • De Vito C; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
  • Villari P; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy - Hospital Hygiene Unit, Policlinico Umberto I Hospital, Rome, Italy.
  • Romano F; Health Directorate, Policlinico Umberto I Hospital, Rome, Italy.
  • De Giusti M; Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy - Hospital Hygiene Unit, Policlinico Umberto I Hospital, Rome, Italy.
Ann Ig ; 31(5): 423-435, 2019.
Article en En | MEDLINE | ID: mdl-31304523
BACKGROUND: Healthcare-associated infection (HAI) is the most frequent adverse event in healthcare settings. It is associated with increased mortality and antimicrobial resistance, leading to prolonged hospital stays and consistent financial loss for healthcare systems. The objective of this study was to estimate the burden of HAIs and antimicrobial use in the Teaching Hospital Policlinico Umberto I (THPUI) of Rome and to identify the most critical areas for intervention. METHODS: Data were collected according to the most recent ECDC point prevalence survey protocol in November 2018. Descriptive statistics for all variables were calculated. Univariate analysis was used to assess possible associations between variables and HAIs. Variables with a significance level of p<0.25 were included in a multiple logistic regression model. RESULTS: A total of 799 patients were included in the analysis; of these, 13.3% presented with at least one HAI. Bloodstream infection was the most common, accounting for 30.9% of total infections. Overall, 125 microorganisms were isolated, with Enterobacteriaceae being the most frequent (32%). At the time of the survey, 49.1% patients were receiving antimicrobial therapy. The multivariate analysis showed a significant association between HAI and use of medical devices (OR=34.30; 95% CI:3.69-318.66), length of stay (OR=1.01; 95% CI:1.00-1.02) and exposure to prophylactic antimicrobial therapy (OR=0.23; 95% CI:0.11-0.47). CONCLUSIONS: The ECDC methodology proved to be applicable to THPUI, where HAI prevalence was higher than the European standard (6.7%). This highlights the need to implement targeted measures to prevent and control HAIs, including continuous monitoring to evaluate the effectiveness of such interventions.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infección Hospitalaria / Equipos y Suministros / Antiinfecciosos Tipo de estudio: Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Ann Ig Asunto de la revista: MICROBIOLOGIA / SAUDE PUBLICA Año: 2019 Tipo del documento: Article País de afiliación: Italia

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Infección Hospitalaria / Equipos y Suministros / Antiinfecciosos Tipo de estudio: Guideline / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Infant / Male País/Región como asunto: Europa Idioma: En Revista: Ann Ig Asunto de la revista: MICROBIOLOGIA / SAUDE PUBLICA Año: 2019 Tipo del documento: Article País de afiliación: Italia