Characterization of active anticoagulant fraction and a fibrin(ogen)olytic serine protease from leaves of Clerodendrum colebrookianum, a traditional ethno-medicinal plant used to reduce hypertension.

Gogoi, Debananda; Ramani, Sheetal; Bhartari, Surbhi; Chattopadhyay, Pronobesh; Mukherjee, Ashis K

Gogoi, Debananda; Ramani, Sheetal; Bhartari, Surbhi; Chattopadhyay, Pronobesh; Mukherjee, Ashis K.

Afiliación

Gogoi D; Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Ramani S; Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Bhartari S; Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India.
Chattopadhyay P; Division of Pharmaceutical Technology, Defense Research Laboratory, Tezpur, 784501, Assam, India.
Mukherjee AK; Microbial Biotechnology and Protein Research Laboratory, Department of Molecular Biology and Biotechnology, School of Sciences, Tezpur University, Tezpur, 784028, Assam, India. Electronic address: akm@tezu.ernet.in.

J Ethnopharmacol ; 243: 112099, 2019 Oct 28.

Article en En | MEDLINE | ID: mdl-31326559

Asunto(s)

Anticoagulantes/uso terapéutico; Clerodendrum; Fibrinolíticos/uso terapéutico; Extractos Vegetales/uso terapéutico; Animales; Anticoagulantes/farmacología; Anticoagulantes/toxicidad; Sistema Enzimático del Citocromo P-450/metabolismo; Factor Xa/metabolismo; Femenino; Fibrina/metabolismo; Fibrinógeno/metabolismo; Fibrinolíticos/farmacología; Fibrinolíticos/toxicidad; Células HEK293; Humanos; Hipertensión/tratamiento farmacológico; Masculino; Medicina Tradicional; Ratones; Extractos Vegetales/farmacología; Extractos Vegetales/toxicidad; Hojas de la Planta; Plantas Medicinales; Serina Endopeptidasas; Trombina/metabolismo; Trombosis/tratamiento farmacológico

Palabras clave

Anticoagulant; Blood thinner; Cardiovascular drug; Medicinal plant; Phytochemicals; Protease

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Extractos Vegetales / Clerodendrum / Fibrinolíticos / Anticoagulantes Límite: Animals / Female / Humans / Male Idioma: En Revista: J Ethnopharmacol Año: 2019 Tipo del documento: Article País de afiliación: India

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