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New alcohol-related genes suggest shared genetic mechanisms with neuropsychiatric disorders.
Evangelou, Evangelos; Gao, He; Chu, Congying; Ntritsos, Georgios; Blakeley, Paul; Butts, Andrew R; Pazoki, Raha; Suzuki, Hideaki; Koskeridis, Fotios; Yiorkas, Andrianos M; Karaman, Ibrahim; Elliott, Joshua; Luo, Qiang; Aeschbacher, Stefanie; Bartz, Traci M; Baumeister, Sebastian E; Braund, Peter S; Brown, Michael R; Brody, Jennifer A; Clarke, Toni-Kim; Dimou, Niki; Faul, Jessica D; Homuth, Georg; Jackson, Anne U; Kentistou, Katherine A; Joshi, Peter K; Lemaitre, Rozenn N; Lind, Penelope A; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Milaneschi, Yuri; Nelson, Christopher P; Nolte, Ilja M; Perälä, Mia-Maria; Polasek, Ozren; Porteous, David; Ratliff, Scott M; Smith, Jennifer A; Stancáková, Alena; Teumer, Alexander; Tuominen, Samuli; Thériault, Sébastien; Vangipurapu, Jagadish; Whitfield, John B; Wood, Alexis; Yao, Jie; Yu, Bing; Zhao, Wei; Arking, Dan E; Auvinen, Juha.
Afiliación
  • Evangelou E; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Gao H; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Chu C; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Ntritsos G; MRC-PHE Centre for Environment and Health, Imperial College London, London, UK.
  • Blakeley P; Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
  • Butts AR; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Pazoki R; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Suzuki H; NIHR Imperial Biomedical Research Centre, ITMAT Data Science Group, Imperial College London, London, UK.
  • Koskeridis F; Molecular Medicine, School of Medicine, University of Utah, Salt Lake City, UT, USA.
  • Yiorkas AM; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Karaman I; Centre for Restorative Neurosciences, Division of Brain Sciences, Department of Medicine, Hammersmith Campus, Imperial College London, London, UK.
  • Elliott J; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
  • Luo Q; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Aeschbacher S; Department of Life Sciences, Brunel University London, London, UK.
  • Bartz TM; Section of Investigative Medicine, Imperial College London, London, UK.
  • Baumeister SE; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Braund PS; UK Dementia Research Institute, Imperial College London, London, UK.
  • Brown MR; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.
  • Brody JA; Institute of Science and Technology for Brain-Inspired Intelligence, MOE-Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China.
  • Clarke TK; Department of Psychology and the Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, UK.
  • Dimou N; Cardiology Division, University Hospital Basel, Basel, Switzerland.
  • Faul JD; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Homuth G; Department of Biostatistics, University of Washington, Seattle, WA, USA.
  • Jackson AU; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
  • Kentistou KA; Chair of Epidemiology, Ludwig-Maximilians-Universitat Munchen, UNIKA-T Augsburg, Augsburg, Germany.
  • Joshi PK; Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
  • Lemaitre RN; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Lind PA; Human Genetics Center, Department of Epidemiology, Human Genetics & Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, USA.
  • Lyytikäinen LP; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Mangino M; Department of Psychiatry, University of Edinburgh, Edinburgh, UK.
  • Milaneschi Y; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
  • Nelson CP; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
  • Nolte IM; Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
  • Perälä MM; Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
  • Polasek O; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Porteous D; Centre for Cardiovascular Sciences, Queens Medical Research Institute, University of Edinburgh, Edinburgh, UK.
  • Ratliff SM; Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
  • Smith JA; Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.
  • Stancáková A; Psychiatric Genetics, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
  • Teumer A; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.
  • Tuominen S; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and LHealth Technology, Tampere University, Tampere, Finland.
  • Thériault S; Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland.
  • Vangipurapu J; Department of Twin Research and Genetic Epidemiology, King's College London, London, UK.
  • Whitfield JB; NIHR Biomedical Research Centre, Guy's and St Thomas Foundation Trust, London, UK.
  • Wood A; Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Center, Amsterdam, the Netherlands.
  • Yao J; Department of Cardiovascular Sciences, University of Leicester, Cardiovascular Research Centre, Glenfield Hospital, Leicester, UK.
  • Yu B; NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK.
  • Zhao W; Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Arking DE; Folkhälsan Research Center, Helsinki, Finland.
  • Auvinen J; Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
Nat Hum Behav ; 3(9): 950-961, 2019 09.
Article en En | MEDLINE | ID: mdl-31358974
ABSTRACT
Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d-1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We identified 46 new common loci and investigated their potential functional importance using magnetic resonance imaging data and gene expression studies. We identify genetic pathways associated with alcohol consumption and suggest genetic mechanisms that are shared with neuropsychiatric disorders such as schizophrenia.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Predisposición Genética a la Enfermedad / Genes / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Consumo de Bebidas Alcohólicas / Predisposición Genética a la Enfermedad / Genes / Trastornos Mentales Tipo de estudio: Diagnostic_studies / Prognostic_studies / Systematic_reviews Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Hum Behav Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido