Novel epidithiodiketopiperazines as anti-viral zinc ejectors of the Feline Immunodeficiency Virus (FIV) nucleocapsid protein as a model for HIV infection.
Bioorg Med Chem
; 27(18): 4174-4184, 2019 09 15.
Article
en En
| MEDLINE
| ID: mdl-31395510
ABSTRACT
Focused libraries of multi-substituted epidithiodiketopiperazines (ETP) were prepared and evaluated for efficacy of inhibiting the nucleocapsid protein function of the Feline Immunodeficiency Virus (FIV) as a model for HIV. This activity was compared and contrasted to observed toxicity utilising an in-vitro cell culture approach. This resulted in the identification of several promising lead compounds with nanomolar potency in cells with low toxicity and a favorable therapeutic index.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Infecciones por VIH
/
Virus de la Inmunodeficiencia Felina
/
Proteínas de la Nucleocápside
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Bioorg Med Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2019
Tipo del documento:
Article