STAG Mutations in Cancer.
Trends Cancer
; 5(8): 506-520, 2019 08.
Article
en En
| MEDLINE
| ID: mdl-31421907
ABSTRACT
Stromal Antigen 1 and 2 (STAG1/2) are key subunits of the cohesin complex that mediate sister chromatid cohesion, DNA repair, transcriptional regulation, and genome topology. Genetic alterations comprising any of the 11 cohesin-associated genes possibly occur in up to 26% of patients included in The Cancer Genome Atlas (TCGA) studies. STAG2 shows the highest number of putative driver truncating mutations. We provide a comprehensive review of the function of STAG1/2 in human physiology and disease and an integrative analysis of available omics data on STAG alterations in a wide array of cancers, comprising 53 691 patients and 1067 cell lines. Lastly, we discuss opportunities for therapeutic intervention.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Proteínas Nucleares
/
Proteínas Cromosómicas no Histona
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Proteínas de Ciclo Celular
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Carcinogénesis
/
Neoplasias
Límite:
Humans
Idioma:
En
Revista:
Trends Cancer
Año:
2019
Tipo del documento:
Article
País de afiliación:
Alemania