Tear Organic Acid Analysis After Corneal Collagen Crosslinking in Keratoconus.
Eye Contact Lens
; 46 Suppl 2: S122-S128, 2020 Mar.
Article
en En
| MEDLINE
| ID: mdl-31425352
ABSTRACT
OBJECTIVES:
This study examined changes in the levels of organic acids, which are important tear metabolites, after corneal collagen crosslinking (CXL) treatment for keratoconus.METHODS:
This prospective, nonrandomized, interventional case series included a single eye from 24 patients who were scheduled to receive CXL treatment (Dresden protocol) for progressive keratoconus. Before CXL treatment and at 6 months after treatment, tears were collected in capillary tubes. The patients were separated into four groups as males, females, and ages 18 years younger and >18 older. The organic acid profiles of the tear samples were analyzed using mass spectrometry.RESULTS:
An evaluation was made of 12 females and 12 males with a mean age of 19.20±4.06 years (range 12[FIGURE DASH]27 years). The greatest percentage increase in organic acids after CXL treatment was observed for N-acetyl-L-aspartic acid (66% increase). The organic acid showing the greatest decrease was 3-OH butyric acid (61% decrease). A decrease of 46% was found (P=0.263) in the lactic acid/malic acid ratio.CONCLUSION:
Metabolomic studies of tears could facilitate a new and objective process in the follow-up period or in the determination of prognosis after CXL treatment for diseases such as keratoconus, which has a multifactorial etiology.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
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Lágrimas
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Ácidos
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Agudeza Visual
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Colágeno
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Reactivos de Enlaces Cruzados
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Queratocono
Tipo de estudio:
Diagnostic_studies
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Guideline
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Observational_studies
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Prognostic_studies
Límite:
Adolescent
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Adult
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Child
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Female
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Humans
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Male
Idioma:
En
Revista:
Eye Contact Lens
Asunto de la revista:
OFTALMOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Turquía