LncRNA AFAP1-AS1 promotes tumorigenesis and epithelial-mesenchymal transition of osteosarcoma through RhoC/ROCK1/p38MAPK/Twist1 signaling pathway.

Shi, Deyao; Wu, Fashuai; Mu, Shidai; Hu, Binwu; Zhong, Binlong; Gao, Feng; Qing, Xiangcheng; Liu, Jianxiang; Zhang, Zhicai; Shao, Zengwu

Shi, Deyao; Wu, Fashuai; Mu, Shidai; Hu, Binwu; Zhong, Binlong; Gao, Feng; Qing, Xiangcheng; Liu, Jianxiang; Zhang, Zhicai; Shao, Zengwu.

Afiliación

Shi D; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Wu F; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Mu S; Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Hu B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Zhong B; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Gao F; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Qing X; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Liu J; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China.
Zhang Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China. zhicaizhang@126.com.
Shao Z; Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, China. szwpro@163.com.

J Exp Clin Cancer Res ; 38(1): 375, 2019 Aug 23.

Article en En | MEDLINE | ID: mdl-31443665

Asunto(s)

Neoplasias Óseas/metabolismo; Proteínas Nucleares/metabolismo; Osteosarcoma/metabolismo; Proteína 1 Relacionada con Twist/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo; Quinasas Asociadas a rho/metabolismo; Proteína rhoC de Unión a GTP/metabolismo; Animales; Neoplasias Óseas/genética; Neoplasias Óseas/patología; Carcinogénesis; Transición Epitelial-Mesenquimal; Femenino; Xenoinjertos; Humanos; Sistema de Señalización de MAP Quinasas; Ratones; Ratones Endogámicos BALB C; Ratones Desnudos; Proteínas Nucleares/genética; Osteosarcoma/genética; Osteosarcoma/patología; ARN Largo no Codificante; Transfección; Proteína 1 Relacionada con Twist/genética; Quinasas Asociadas a rho/genética; Proteína rhoC de Unión a GTP/genética

Palabras clave

AFAP1-AS1; Epithelial-mesenchymal transition; Long non-coding RNA; Osteosarcoma; RhoC; Twist1

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Neoplasias Óseas / Proteínas Nucleares / Osteosarcoma / Proteínas Quinasas p38 Activadas por Mitógenos / Proteína 1 Relacionada con Twist / Quinasas Asociadas a rho / Proteína rhoC de Unión a GTP Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans Idioma: En Revista: J Exp Clin Cancer Res Año: 2019 Tipo del documento: Article País de afiliación: China

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