Daily administration of Sake Lees (Sake Kasu) reduced psychophysical stress-induced hyperalgesia and Fos responses in the lumbar spinal dorsal horn evoked by noxious stimulation to the hindpaw in the rats.
Biosci Biotechnol Biochem
; 84(1): 159-170, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31483212
ABSTRACT
We tested whether Sake Lees (SL) had inhibitory effects on hyperalgesia in the hindpaw under psychophysical stress conditions. Male rats were subjected to repeated forced swim stress treatments (FST) from Day -3 to Day -1. Intraperiotoneal administration of SL which contained low concentration of ethanol (SLX) was conducted after each FST. On Day 0, formalin-evoked licking behaviors and Fos responses in the lumbar spinal cord (DH) and several areas within the rostral ventromedial medulla (RVM) were quantified as nociceptive responses. FST-induced hyperalgesia in the hindpaw was prevented by repeated SL and SLX treatments. Fos expression was significantly increased in DH and some areas within the RVM under FST, which was prevented by repeated SL or SLX. These findings indicated that daily administration of SL had the potential to alleviate stress-induced hyperalgesia.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Oryza
/
Estrés Fisiológico
/
Extractos Vegetales
/
Proteínas Proto-Oncogénicas c-fos
/
Fermentación
/
Asta Dorsal de la Médula Espinal
/
Miembro Posterior
/
Hiperalgesia
Tipo de estudio:
Etiology_studies
Límite:
Animals
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Asunto de la revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Japón