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The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Rudolf, Amalie F; Kinnebrew, Maia; Kowatsch, Christiane; Ansell, T Bertie; El Omari, Kamel; Bishop, Benjamin; Pardon, Els; Schwab, Rebekka A; Malinauskas, Tomas; Qian, Mingxing; Duman, Ramona; Covey, Douglas F; Steyaert, Jan; Wagner, Armin; Sansom, Mark S P; Rohatgi, Rajat; Siebold, Christian.
Afiliación
  • Rudolf AF; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Kinnebrew M; Departments of Biochemistry and Medicine, Stanford University School of Medicine, Stanford, CA, USA.
  • Kowatsch C; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Ansell TB; Department of Biochemistry, University of Oxford, Oxford, UK.
  • El Omari K; Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
  • Bishop B; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Pardon E; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Schwab RA; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.
  • Malinauskas T; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Qian M; Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
  • Duman R; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Covey DF; Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
  • Steyaert J; Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Wagner A; Structural Biology Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
  • Sansom MSP; VIB-VUB Center for Structural Biology, VIB, Brussels, Belgium.
  • Rohatgi R; Science Division, Diamond Light Source, Harwell Science and Innovation Campus, Didcot, UK.
  • Siebold C; Department of Biochemistry, University of Oxford, Oxford, UK.
Nat Chem Biol ; 15(10): 975-982, 2019 10.
Article en En | MEDLINE | ID: mdl-31548691
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Hedgehog / Receptor Patched-1 Límite: Animals / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Proteínas Hedgehog / Receptor Patched-1 Límite: Animals / Humans Idioma: En Revista: Nat Chem Biol Asunto de la revista: BIOLOGIA / QUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Reino Unido