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High Serum DNA and RNA Oxidative Damage in Non-surviving Patients with Spontaneous Intracerebral Hemorrhage.
Lorente, Leonardo; Martín, María M; González-Rivero, Agustín F; Pérez-Cejas, Antonia; Abreu-González, Pedro; Sabatel, Rafael; Ramos, Luis; Argueso, Mónica; Cáceres, Juan J; Solé-Violán, Jordi; Jiménez, Alejandro; García-Marín, Victor.
Afiliación
  • Lorente L; Intensive Care Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain. lorentemartin@msn.com.
  • Martín MM; Intensive Care Unit, Hospital Universitario Nuestra Señora de Candelaria, Crta del Rosario s/n, 38010, Santa Cruz de Tenerife, Spain.
  • González-Rivero AF; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
  • Pérez-Cejas A; Laboratory Department, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
  • Abreu-González P; Department of Physiology, Faculty of Medicine, University of the La Laguna, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
  • Sabatel R; Department of Radiology, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
  • Ramos L; Intensive Care Unit, Hospital General La Palma, Buenavista de Arriba s/n, Breña Alta, 38713, La Palma, Spain.
  • Argueso M; Intensive Care Unit, Hospital Clínico Universitario de Valencia, Avda, Blasco Ibáñez no. 17-19, 46004, Valencia, Spain.
  • Cáceres JJ; Intensive Care Unit, Hospital Insular, Plaza Dr, Pasteur s/n, 35016, Las Palmas de Gran Canaria, Spain.
  • Solé-Violán J; Intensive Care Unit, Hospital Universitario Dr. Negrín, Barranco de la Ballena s/n, 35010, Las Palmas de Gran Canaria, Spain.
  • Jiménez A; Research Unit, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
  • García-Marín V; Department of Neurosurgery, Hospital Universitario de Canarias, Ofra, s/n, La Laguna, 38320, Santa Cruz de Tenerife, Spain.
Neurocrit Care ; 33(1): 90-96, 2020 08.
Article en En | MEDLINE | ID: mdl-31598840
PURPOSE: One study found higher leukocytes 8-hydroxy-2'-deoxyguanosine (8-OHdG) levels in patients with spontaneous intracerebral hemorrhage (ICH) than in healthy subjects due to the oxidation of guanosine from deoxyribonucleic acid (DNA). The objective of this study was to determine whether there is an association between oxidative damage of serum DNA and ribonucleic acid (RNA) and mortality in patients with ICH. METHODS: In this observational and prospective study, patients with severe supratentorial ICH (defined as Glasgow Coma Scale < 9) were included from six Intensive Care Units of Spanish hospitals. At the time of severe ICH diagnosis, concentrations in serum of malondialdehyde (as lipid peroxidation biomarker) and of the three oxidized guanine species (OGS) (8-hydroxyguanosine from RNA, 8-hydroxyguanine from DNA or RNA, and 8-OHdG from DNA) were determined. Thirty-day mortality was considered the end-point study. RESULTS: Serum levels of OGS (p < 0.001) and malondialdehyde (p = 0.002) were higher in non-surviving (n = 46) than in surviving patients (n = 54). There was an association of serum OGS levels with serum malondialdehyde levels (rho = 0.36; p = 0.001) and 30-day mortality (OR = 1.568; 95% CI 1.183-2.078; p = 0.002). CONCLUSIONS: The novel and most important finding of our study was that serum OGS levels in ICH patients are associated with mortality.
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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / ARN / Hemorragia Cerebral / Mortalidad / Estrés Oxidativo / 8-Hidroxi-2'-Desoxicoguanosina / Guanina / Guanosina Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurocrit Care Asunto de la revista: NEUROLOGIA / TERAPIA INTENSIVA Año: 2020 Tipo del documento: Article País de afiliación: España

Texto completo: 1 Bases de datos: MEDLINE Asunto principal: ADN / ARN / Hemorragia Cerebral / Mortalidad / Estrés Oxidativo / 8-Hidroxi-2'-Desoxicoguanosina / Guanina / Guanosina Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Neurocrit Care Asunto de la revista: NEUROLOGIA / TERAPIA INTENSIVA Año: 2020 Tipo del documento: Article País de afiliación: España