Expression of IL-1ß, HMGB1, HO-1, and LDH in malignant and non-malignant pleural effusions.
Respir Physiol Neurobiol
; 272: 103330, 2020 01.
Article
en En
| MEDLINE
| ID: mdl-31639457
ABSTRACT
IL-1ß, HMGB1, HO-1, and LDH in the pleural effusions (PE) of patients with transudative, infectious, and malignant etiologies were determined using ELISA and enzymatic assays. IL-1ß, HMGB1, HO-1, and LDH showed significant differences between the three etiologies. Post-hoc analysis revealed higher levels of HO-1 and HMGB1 in infectious versus transudative effusion. Higher levels of IL-1ß were found in infectious versus transudative or malignant effusion. The comparison of LDH levels showed significant differences. Positive correlations were found between IL-1ß, HMGB1, and LDH in infectious effusions. The samples were then divided into cancerous and non-cancerous groups, and logistic regression revealed that increasing IL-1ß levels were significantly associated with a decrease in cancer risk after adjusting for HMGB1, HO-1, and LDH. Our findings suggest that IL-1ß, HMGB1, HO-1, and LDH are expressed differently, with positive correlations between HMGB1, IL-1ß, and LDH in infectious effusions, and low IL-1ß expression in malignant effusions.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Derrame Pleural
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Proteína HMGB1
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Hemo-Oxigenasa 1
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Interleucina-1beta
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Infecciones
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Inflamación
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L-Lactato Deshidrogenasa
Tipo de estudio:
Observational_studies
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Prevalence_studies
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Risk_factors_studies
Límite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Respir Physiol Neurobiol
Año:
2020
Tipo del documento:
Article