CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells.
Nat Commun
; 10(1): 4987, 2019 11 01.
Article
en En
| MEDLINE
| ID: mdl-31676770
ABSTRACT
Bystander activation of memory T cells occurs in the absence of cognate antigen during infections that elicit strong systemic inflammatory responses, which subsequently affect host immune responses. Here we report that memory T cell bystander activation is not limited to induction by systemic inflammation. We initially observe potential T cell bystander activation in a cohort of human vaccine recipients. Using a mouse model system, we then find that memory CD8+ T cells are specifically recruited to sites with activated antigen-presenting cells (APCs) in a CXCR3-dependent manner. In addition, CXCR3 is also necessary for T cell clustering around APCs and T cell bystander activation, which temporospatially overlaps with the subsequent antigen-specific T cell response. Our data thus suggest that bystander activation is part of the initial localized immune response, and is mediated by a site-specific recruitment process of memory T cells.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Activación de Linfocitos
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Linfocitos T CD8-positivos
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Efecto Espectador
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Receptores CXCR3
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Memoria Inmunológica
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Células Presentadoras de Antígenos
Límite:
Animals
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Female
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Humans
Idioma:
En
Revista:
Nat Commun
Asunto de la revista:
BIOLOGIA
/
CIENCIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Estados Unidos