Platelet reactivity in patients with chronic kidney disease and hemodialysis.
J Thromb Thrombolysis
; 49(1): 168-172, 2020 Jan.
Article
en En
| MEDLINE
| ID: mdl-31691067
ABSTRACT
End stage renal disease requiring hemodialysis (HD) is frequent and coronary artery disease (CAD) is a common comorbidity. It is associated with bleeding and ischemic events. Platelet reactivity is a well-known determinant of both. However, the impact of HD due to end stage chronic kidney disease (CKD) on platelet reactivity is unknown. Therefore in this study, we evaluated platelet reactivity during hemodialysis in patients with CKD and coronary artery disease. 22 patients with CKD, HD and CAD were included in this study. Light transmission aggregometry (LTA) and flow cytometry were used for evaluating platelet function immediately before and 2 h after initiation of HD. Arachidonic acid-induced maximum of aggregation (MoApre HD 27.36% ± 25.23% vs. MoAduring HD 28.05% ± 23.50%, p value = 0.822), adenosine diphosphate (ADP)-induced platelet aggregation (MoApre HD 65.36% ± 12.88% vs. MoAduring HD 61.55% ± 17.17%, p-value = 0.09) and collagen-induced platelet aggregation (MoApre HD 62.18% ± 18.14% vs. MoAduring HD 64.82% ± 18.31%, p-value = 0.375) were not affected by HD. P-selectin expression was significantly lower after 2 h of HD (pre HD 31.56% ± 18.99%, during HD 23.97% ± 15.28%, p = 0.026). In this pilot study, HD did not enhance platelet aggregation. Baseline platelet reactivity was decreased during HD.
Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Activación Plaquetaria
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Diálisis Renal
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Insuficiencia Renal Crónica
/
Hemorragia
Tipo de estudio:
Etiology_studies
Límite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Thromb Thrombolysis
Asunto de la revista:
ANGIOLOGIA
Año:
2020
Tipo del documento:
Article
País de afiliación:
Alemania