Encapsulation of Upconversion Nanoparticles in Periodic Mesoporous Organosilicas.
Molecules
; 24(22)2019 Nov 09.
Article
en En
| MEDLINE
| ID: mdl-31717490
ABSTRACT
(1) Background:
Nanomedicine has recently emerged as a promising field, particularly for cancer theranostics. In this context, nanoparticles designed for imaging and therapeutic applications are of interest. We, therefore, studied the encapsulation of upconverting nanoparticles in mesoporous organosilica nanoparticles. Indeed, mesoporous organosilica nanoparticles have been shown to be very efficient for drug delivery, and upconverting nanoparticles are interesting for near-infrared and X-ray computed tomography imaging, depending on the matrix used. (2)Methods:
Two different upconverting-based nanoparticles were synthesized with Yb3+-Er3+ as the upconverting system and NaYF4 or BaLuF5 as the matrix. The encapsulation of these nanoparticles was studied through the sol-gel procedure with bis(triethoxysilyl)ethylene and bis(triethoxysilyl)ethane in the presence of CTAB. (3)Results:
with bis(triethoxysilyl)ethylene, BaLuF5 Yb3+-Er3+, nanoparticles were not encapsulated, but anchored on the surface of the obtained mesoporous nanorods BaLuF5 Yb3+-Er3+@Ethylene. With bis(triethoxysilyl)ethane, BaLuF5 Yb3+-Er3+ and NaYF4 Yb3+-Er3+nanoparticles were encapsulated in the mesoporous cubic structure leading to BaLuF5 Yb3+-Er3+@Ethane and NaYF4 Yb3+-Er3+@Ethane, respectively. (4)Conclusions:
upconversion nanoparticles were located on the surface of mesoporous nanorods obtained by hydrolysis polycondensation of bis(triethoxysilyl)ethylene, whereas encapsulation occurred with bis(triethoxysilyl)ethane. The later nanoparticles NaYF4 Yb3+-Er3+@Ethane or BaLuF5 Yb3+-Er3+@Ethane were promising for applications with cancer cell imaging or X-ray-computed tomography respectively.Palabras clave
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
Compuestos de Organosilicio
/
Nanopartículas
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
Francia