Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression.
Trends Immunol
; 40(12): 1120-1133, 2019 12.
Article
en En
| MEDLINE
| ID: mdl-31744765
ABSTRACT
Inflammation benefits the host by promoting the elimination of invading pathogens and clearance of cellular debris after tissue injury. Inflammation also stimulates tissue repair and regeneration to restore homeostasis and organismal health. Emerging evidence suggests that mitochondrial DNA (mtDNA), the only form of non-nuclear DNA in eukaryotic cells, is a major activator of inflammation when leaked out from stressed mitochondria. Here, we review the current understanding on the role of mtDNA in innate immunity, discussing how dysregulated mtDNA metabolism can promote chronic inflammation and disease progression.
Texto completo:
1
Bases de datos:
MEDLINE
Asunto principal:
ADN Mitocondrial
/
Inmunidad Innata
/
Inflamación
/
Mitocondrias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Immunol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
Año:
2019
Tipo del documento:
Article
País de afiliación:
China