Efficient nonenzymatic cyclization and domain shuffling drive pyrrolopyrazine diversity from truncated variants of a fungal NRPS.

Berry, Daniel; Mace, Wade; Grage, Katrin; Wesche, Frank; Gore, Sagar; Schardl, Christopher L; Young, Carolyn A; Dijkwel, Paul P; Leuchtmann, Adrian; Bode, Helge B; Scott, Barry

Berry, Daniel; Mace, Wade; Grage, Katrin; Wesche, Frank; Gore, Sagar; Schardl, Christopher L; Young, Carolyn A; Dijkwel, Paul P; Leuchtmann, Adrian; Bode, Helge B; Scott, Barry.

Afiliación

Berry D; School of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand.
Mace W; Bioprotection Research Centre, Massey University, Palmerston North 4442, New Zealand.
Grage K; Grasslands Research Centre, AgResearch Ltd., Palmerston North 4442, New Zealand.
Wesche F; School of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand.
Gore S; Fachbereich Biowissenschaften, Molekulare Biotechnologie, Goethe Universität Frankfurt, 60438 Frankfurt am Main, Germany.
Schardl CL; Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute, 07745 Jena, Germany.
Young CA; Department of Plant Pathology, University of Kentucky, Lexington, KY 40506.
Dijkwel PP; Noble Research Institute, LLC, Ardmore, OK 73401.
Leuchtmann A; School of Fundamental Sciences, Massey University, Palmerston North 4442, New Zealand.
Bode HB; Bioprotection Research Centre, Massey University, Palmerston North 4442, New Zealand.
Scott B; Institute of Integrative Biology, ETH Zürich, CH-8092 Zürich, Switzerland.

Proc Natl Acad Sci U S A ; 116(51): 25614-25623, 2019 12 17.

Article en En | MEDLINE | ID: mdl-31801877

Asunto(s)

Péptido Sintasas; Pirazinas; Ciclización/genética; Barajamiento de ADN; Dicetopiperazinas/química; Epichloe/enzimología; Epichloe/genética; Proteínas Fúngicas/química; Proteínas Fúngicas/genética; Proteínas Fúngicas/metabolismo; Péptido Sintasas/química; Péptido Sintasas/genética; Péptido Sintasas/metabolismo; Pirazinas/química; Pirazinas/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo

Palabras clave

allelic neofunctionalization; diketopiperazine; nonribosomal peptide synthetase; pyrrolopyrazine; secondary metabolism

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Texto completo: 1 Bases de datos: MEDLINE Asunto principal: Péptido Sintasas / Pirazinas Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2019 Tipo del documento: Article País de afiliación: Nueva Zelanda

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